This 32GB memory is 100% compatible with Lenovo System x3650 M4 HD (5460). Our memory team will be happy to assist you in choosing the right memory and configuring your server.technologymax. RAM 1 x CPUmax. RAM 2 x CPURam per CPU (12 memory slots, 3x memory slot à 4 memory channels)UDIMM ECC64GB RAM (8 x 8GB ECC UDIMM)128GB RAM (16 x 8GB ECC UDIMM)RDIMM192GB RAM (12 x 16GB RDIMM)384GB RAM (24 x 16GB RDIMM)LRDIMM384GB RAM (12 x 32GB LRDIMM)768GB RAM (24 x 32GB RDIMM)ECC DIMM, Registered DIMM and Load Reduced LRDIMM memory modules may not be mixed.not be mixed. When upgrading, you should therefore know which memory is already present or upgrade completely to RDIMM memory.Memory configuration principlesThere are 4 memory channels per CPU, each with 3 memory slotsECC DIMM, Registered DIMM and Load Reduced LRDIMM memory modules must not be mixedWhen using ECC UDIMM or 4Rank (4Rx..) RDIMM memory modules, only 2 of 3 memory slots per memory channel can be occupiedMemory slots for which no processor is available must not be fittedMemory configuration for good system performancer a good system performanceDistribute the memories evenly across the memory slots and evenly across the CPUsIf more than one CPU is available, the memories per CPU should be populated identically (mirrored to the other CPU).