Yes, you can connect the mixer directly to the PS5 via USB-C, this is officially supported. It gets more complicated with the Astro A50: According to the manufacturer, wireless headsets are generally not suitable, only wired 3.5 mm headsets or headsets with DAC and a suitable 3.5 mm connection. I am therefore not completely sure whether your A50 set with its base station can really be used sensibly and stably with the device; the available information does not clearly cover this case. The best thing to do is to ask our Community for specific experience with this headset.