Yes, you can, but then some "components/functions" are not available. Namely, everything that is controlled via the second CPU, such as the DIMMs 7 to 12 or the PCI-E slots 5 to 7.

I can only advise extra caution with regard to the chapter on power supply! In the manual

E13119b
Revised Edition V2
August 2017

There is a serious error on page 1-28 of this mainboard!
The power socket EATX12V3 (D) stated on page 1-28 is WRONG!!!
The polarities are exactly reversed! If the system is assembled as described in this manual, a direct short circuit will be generated!

Yes