The Magic Mouse 2 is compatible with macOS Catalina, as it requires a Bluetooth-enabled Mac with OS X 10.11 or later, which includes Catalina (macOS 10.15). Users have reported successful use of the Magic Mouse 2 on iMacs running Catalina, provided the mouse is properly paired using the Lightning to USB cable supplied.

However, some users have experienced issues with Bluetooth performance such as cursor skipping or lagging specifically on Catalina, which appear to be related to the Bluetooth stack in that macOS version rather than the mouse itself. These issues are not universal but have been reported in community discussions.

In summary, the Magic Mouse 2 is officially compatible with macOS Catalina, but some users may encounter Bluetooth-related performance problems depending on their system configuration.