The HP OfficeJet 250 mobile printer is generally compatible with macOS Sequoia version 15.4.1, provided the latest drivers from HP are installed. It is recommended to download the latest drivers from the HP support page, completely uninstall existing HP printer drivers, reset the printing system on the Mac and add the printer again. It should also be ensured that both the MacBook Pro and the printer are in the same WLAN and that the HP apps (e.g. HP Easy Scan or HP Smart) have the necessary access rights. These steps will help to resolve known issues with compatibility and functionality after the macOS update.