The main difference between the normal combo and the business combo lies in the connection technology and the security functions. The business version often uses the Logi Bolt Receiver, which offers more secure connections, while the normal version often uses the Unifying Receiver. In addition, the business version can be specially optimised for IT departments to provide an improved user experience and easier maintenance.

Other differences may lie in the mouse model version, as the business version is often equipped with the MX Master 3S, which features a MagSpeed wheel and Quiet Click technology.

The normal combo, on the other hand, could be characterised by simpler operation and fewer operational requirements.