Hello, to answer your question: yes, absolutely, every time I change the sheets on my bed I spray the mattress and my cushions, the smell is extremely pleasant and this product is very gentle, so you don't risk any irritation or anything else ... if I can advise you, spray sparingly, because this product is very effective, while also caring for your textiles (bed, sofa, curtains, cushions etc ....), so don't hesitate to spray your mattress!
I hope I've been able to help you. Please accept my best wishes.