Humanity is in great danger as four different plagues threaten the Earth. Players take on the role of highly skilled members of a disease control team to combat these threats. They travel around the world to contain the risks of infection while also laying the groundwork for researching cures. Everyone must contribute their respective strengths to defeat the plagues. In this cooperative game hit, nominated for the Game of the Year award in 2009, all players either win or lose together. Different difficulty levels also maintain the high replay value over the long term.