The patented shape supports the hand in an upright neutral position and generally prevents the forearm from twisting. Many users, including doctors, ergonomics experts, and physical therapists, report that the Evoluent Vertical provides the highest comfort and alleviates wrist pain. The shape is designed for uncompromising comfort, and the programmable buttons are thoughtfully placed, so no finger contortions are necessary to operate them. The pointer speed controls on the side allow for convenient adjustments without releasing the mouse.

The thumb rest has been redesigned compared to previous versions to offer even more comfort. The top-mounted LEDs through the chrome thumb rest indicate the selected pointer speed: extra low (XL), low (LO), medium (MD), and high (HI). A new bottom thumb button provides significantly expanded functionality when used with the included driver. The logo is attractively designed. The lighting turns off when the system is in sleep mode to conserve the notebook battery. An extra-wide lip along the bottom edge prevents the last finger from rubbing against the desk. Evoluent Mouse - Manager for Windows offers extensive yet easy-to-use functionality for 6 buttons through a simple and intuitive interface.